Preheat oven to 400°F. Line a sheet pan with a baking rack and spray lightly with oil or non-stick cooking spray.

Pat the tilapia fillets dry. On a plate, mix together bread crumbs, thyme, garlic powder, red pepper flakes, salt and pepper.

Spread ½ teaspoon of mayonnaise on one side of each piece of tilapia. Invert each piece onto the breadcrumb mixture, press firmly, and place on the prepared baking rack, breadcrumb-side up. Repeat with remaining fillets.

Bake for 15-20 minutes, until the fish flakes easily with a fork.